Researchers

Andrew Paterson, MD
Senior Scientist
Director of Statistical Analysis Facility of TCAG, Hospital for Sick Children
Email: andrew.paterson@utoronto.ca
Phone: 416-813-6994

Senior Scientist, SickKids Research Institute, Toronto. Dr. Paterson obtained his MD in the UK, and has been a Scientist (and more recently a Senior Scientist) in the Genetics and Genome Biology program at SickKids Research Institute since 2001. Over the last 6 years, he has also been the Director of the Statistical Analysis Facility of the Centre for Applied Genomics (TCAG) at SickKids. He has supervised 4 post doctoral and doctoral trainees, is an Associate Professor at the School of Public Health, Faculty of Medicine and Assistant Professor, Neuroscience Program and Department of Psychiatry, both at the University of Toronto. Paterson’s research focus is in the genetic basis of common diseases using a genome-wide approach. He was awarded the Canada Research Chair in the Genetics of Complex Diseases in 2002. His main focus is on the genetic basis of complex disease, specifically type 1 diabetes and its long-term complications. Paterson leads a genome-wide study on diabetic complications involving over 1,300 subjects as part of the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. His team has studied a large number of families in Newfoundland and Labrador (Canada), where the incidence of this disease is among the highest in the world. His research team identified a common genetic variation in the superoxide dismutase 1 gene association with diabetic nephropathy. Work currently under review has identified two novel susceptibility loci for type 1 diabetes, as well as a major genetic locus that accounts for 20% of the variance in soluble e-selectin levels. More recently, his team has designed the study and analyzed the data from ~ 860K common SNPs from the Illumina 1M chip with retinal, renal, cardiovascular and neurological complications and their risk factors in 1304 white probands from the Diabetes Control & Complications Trial (DCCT)/Epidemiology of Diabetes Interventions & Complications (EDIC) study and the Genetics of Kidneys in Diabetes (GoKinD). Dr. Paterson has co-authored 106 peer-reviewed publications, with several in high impact journals such as Nature Genetics and Science. He is a co-inventor on 4 patents and a reviewer for the NIH and the Canadian Institutes for Health Research.  

 

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